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JmjC domain-containing histone demethylation protein 2A; Jumonji domain-containing protein 1A (JMJD1A, JHDM2A, JMJD1, KDM3A, KIAA0742)
Function:
1) histone demethylase
2) specifically demethylates Lys-9 of histone H3, thus plays a central role in histone code
3) preferentially demethylates mono- & dimethylated H3 Lys-9 residue, with a preference for dimethylated residue
- weak or no activity on trimethylated H3 Lys-9
4) demethylation of Lys generates formaldehyde & succinate
5) role in hormone-dependent transcriptional activation, by participating to recruitment to androgen-receptor target genes, resulting in H3 Lys-9 demethylation & transcriptional activation
Cofactor: binds 1 Fe+2 per subunit
Structure:
- belongs to the JHDM2 histone demethylase family.
- contains 1 JmjC domain JmjC domain & the C6-type zinc-finger are required for demethylation activity
- Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate association with nuclear receptors
Compartment: nucleus
General
dioxygenase
histone demethylase
JmjC domain-containing protein (JMJD)
zinc finger protein
Properties
SIZE: MW = 147 kD
entity length = 1321 aa
COMPARTMENT: cell nucleus
MOTIF: Zinc finger
NAME: Zinc finger
SITE: 662-687
EFFECTOR-BOUND: Zn+2
LXXLL {885-889}
JmjC {1058-1281}
MOTIF: Iron [Fe]-binding site
SITE: 1120-1120
Iron [Fe]-binding site
SITE: 1122-1122
Iron [Fe]-binding site
SITE: 1249-1249
Database Correlations
UniProt Q9Y4C1
Pfam PF02373
References
UniProt :accession Q9Y4C1