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Janus kinase inhibitor; JAK inhibitor
Indications:
- rheumatoid arthritis
- psoriatic arthritis
- plaque psoriasis
- ulcerative colitis
- juvenile idiopathic arthritis
- ankylosing spondylitis
Adverse effects:
- increased all-cause mortality, including sudden cardiovascular death
- majoradverse cardiovascular events
- thrombosis, deep venous thrombosis, pulmonary embolism [2]
- malignancies (excluding non-melanoma skin cancer)
* boxed warning:
- risks of serious heart-related events, cancer, blood clots, & death
Mechanism of action:
- inhibitors of Janus kinase
- current Janus kinase inhibitors are also small inhibitory antineoplastic agents
Interactions
drug adverse effects (more general classes)
Related
Janus kinase (JAK)
Specific
baricitinib (Olumiant)
delgocitinib
deucravacitinib (Sotyktu)
deuruxolitinib (Leqselvi)
ilunocitinib (Zenrelia)
momelotinib (Ojjaara)
ritlecitinib (Litfulo)
tofacitinib (Xeljanz)
upadacitinib (Rinvoq, ABT-494)
General
small inhibitory antineoplastic agent (ib drug)
tyrosine kinase inhibitor
Properties
INHIBITS: protein kinase
References
- FDA MedWatch. Safety Information. Sept 1, 2021
Janus Kinase (JAK) inhibitors: Drug Safety Communication -
FDA Requires Warnings about Increased Risk of Serious Heart-related Events,
Cancer, Blood Clots, and Death.
https://www.fda.gov/safety/medical-product-safety-information/janus-kinase-jak-inhibitors-drug-safety-communication-fda-requires-warnings-about-increased-risk
- Harris S
JAK Inhibitors Increased VTE Risk in People With Inflammatory Disease
Link appears to be soft, but caution advised for higher-risk patients who use
agents for extended periods.
MedPage Today December 30, 2022
https://www.medpagetoday.com/reading-room/acrr/psoriaticarthritis/102442
- Maqsood MH, Weber BN, Haberman RH et al
Cardiovascular and Venous Thromboembolic Risk With Janus Kinase Inhibitors in
Immune-Mediated Inflammatory Diseases: A Systematic Review and Meta-Analysis
of Randomized Trials.
ACR Open Rheumatol. 2022 Oct;4(10):912-922
PMID: 35903881 PMCID: PMC9555201 Free PMC article
https://onlinelibrary.wiley.com/doi/full/10.1002/acr2.11479