Search
Janus kinase & microtubule-interacting protein 1 (GABA-B receptor-binding protein, multiple alpha-helices & RNA-linker protein 1, Marlin-1, JAKMIP1, GABABRBP, JAMIP1, MARLIN1)
Function:
- associates with microtubules
- may play a role in the microtubule-dependent transport of the GABA-B receptor
- may play a role in JAK1 signaling & regulate microtubule cytoskeleton rearrangements
- forms a complex with GABBR1 & KIF5B/kinesin- 1
- interacts with JAK1 & TYK2
- phosphorylated
Structure:
- homodimer
- belongs to the JAKMIP family
Compartment:
- cytoplasm, peripheral membrane
- colocalizes with the microtubule network
- localizes to the cell body & neurites of hippocampal neurons where it accumulates in granules
- localizes to the tail & to a lower extent to the head of sperm cells
Alternative splicing: named isoforms=6
Expression:
- predominantly expressed in neural tissues & lymphoid cells (at protein level)
- isoforms 2, 3 & 4 are specifically expressed in brain & retina while isoform 1 & isoform 5 are also detected in liver, lung & skelelal muscle
- also detected in testis & to a lower extent spleen & intestine
Note:
- originally thought to bind single-stranded RNA molecules & regulate GABA-B receptor expression
General
cytoskeletal protein
phosphoprotein
Properties
SIZE: entity length = 626 aa
MW = 73 kD
COMPARTMENT: cytoplasm
MOTIF: Mediates association with microtubules {1-365}
MOTIF: coiled coil {19-255}
coiled coil {284-413}
Mediates interaction with TYK2 and GABBR1 {365-626}
MOTIF: coiled coil {490-604}
Database Correlations
UniProt Q96N16
Kegg hsa:1527
References
- UniProt :accession Q96N16
- untitled
PMID: 14718537