Search
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase; I-beta-1,3-N-acetylglucosaminyltransferase; iGnT; poly-N-acetyllactosamine extension enzyme; UDP-GlcNAc:betagal beta-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1, B3GNT6)
Function:
- can initiate synthesis or elongation of linear poly-N-acetyllactosaminoglycans
- protein modification; protein glycosylation
Compartment:
- Golgi membrane; single-pass type 2 membrane protein
Expression:
- in the adult
a) highly expressed in heart, brain, skeletal muscle & kidney
b) lower expression in placenta, pancreas, spleen, prostate, testis, ovary, small intestine & colon
c) very weak expression in lung, liver, thymus & peripheral blood leukocytes
- in fetus
a) highly expressed in brain & kidney
b) lower expression in lung & liver
General
beta-1,3-N-acetylglucoaminyltransferase (B3GNT1)
glycoprotein
membrane protein
Properties
SIZE: entity length = 415 aa
MW = 47 kD
COMPARTMENT: golgi
MOTIF: transmembrane domain {9-36}
N-glycosylation site {N204}
N-glycosylation site {N300}
Database Correlations
OMIM 605517
UniProt O43505
Entrez Gene 11041
Kegg hsa:11041
ENZYME 2.4.1.149
References
- UniProt :accession O43505
- GGDB; Note: glycogene database
http://riodb.ibase.aist.go.jp/rcmg/ggdb/
- SeattleSNPs
http://pga.gs.washington.edu/data/b3gnt6/
- Functional glycomics gateway - GTase;
Note: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase
http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewglycoEnzyme.jsp?gbpId=gt_hum_547