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I-alpha-I like inhibitor (I-alpha-LI)
Function:
- carrier of hyaluronan in serum (putative)
- binding protein between hyaluronan & other matrix proteins, including those on cell surfaces
- may regulate localization, synthesis & degradation of hyaluronan
Structure:
- subunits: ITIH2 & bikunin
Compartment: plasma: presumptive inter-alpha-globulin
General
inter alpha globulin
molecular complex
protease inhibitor
Properties
COMPARTMENT: plasma
INHIBITS: protease
SUBUNITS: inter alpha antitrypsin heavy chain-2
MOTIF: signal sequence {1-18}
Ser phosphorylation site {S60}
N-glycosylation site {N96}
N-glycosylation site {N118}
cysteine residue {C261}
MODIFICATION: cysteine residue {C264}
cysteine residue {C264}
MODIFICATION: cysteine residue {C261}
VWFA domain {308-468}
MOTIF: N-glycosylation site {N445}
cysteine residue {C650}
MODIFICATION: cysteine residue {C651}
cysteine residue {C651}
MODIFICATION: cysteine residue {C650}
Thr glycosylation site {T666}
N-glycosylation site {N671}
Ser glycosylation site {S673}
Thr glycosylation site {T675}
Thr glycosylation site {T691}
binding site
SITE: 702-702
FOR-BINDING-OF: Chondroitin 4-sulfate (covalent)
alpha-1 microglobulin
MOTIF: signal sequence {1-19}
Thr glycosylation site {T24}
N-glycosylation site {N36}
cysteine residue {C91}
MODIFICATION: cysteine residue {C188}
N-glycosylation site {N115}
cysteine residue {C188}
MODIFICATION: cysteine residue {C91}
GLYCOPEPTIDE (SECRETORY) {206-226}
MOTIF: Ser glycosylation site {S215}
Kunitz-type serine protease inhibitor [KPI] domain {231-337} (2)
MOTIF: cysteine residue {C231}
MODIFICATION: cysteine residue {C281}
cysteine residue {C240}
MODIFICATION: cysteine residue {C264}
N-glycosylation site {N250}
cysteine residue {C256}
MODIFICATION: cysteine residue {C277}
cysteine residue {C264}
MODIFICATION: cysteine residue {C240}
cysteine residue {C277}
MODIFICATION: cysteine residue {C256}
cysteine residue {C281}
MODIFICATION: cysteine residue {C231}
FOR-BINDING-OF: serine protease
References
UniProt :accession P19823
Components
alpha-1 microglobulin; alpha-1 antitrypsin light chain; protein HC; bikunin (a lipocalin, AMBP, HCP, ITIL)
inter alpha antitrypsin heavy chain-2 (ITI heavy chain H2, inter-alpha-inhibitor heavy chain 2, inter-alpha-trypsin inhibitor complex component II, serum-derived hyaluronan-associated protein, SHAP, ITIH2, IGHEP2)