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C-C motif chemokine 1; small-inducible cytokine A1; T lymphocyte-secreted protein I-309 (CCL1 SCYA1)

Function: - cytokine - chemotactic for monocytes - not chemtactic for neutrophils - binds to CCR8 Structure: - monomer - belongs to the intercrine beta (chemokine CC) family Compartment: secreted Expression: - induced by phorbol myristate acetate (PMA)

Interactions

molecular events

Related

TCA3 or I-309 primary response gene

General

CC chemokine; beta chemokine

Properties

SIZE: entity length = 96 aa MW = 11 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-23} cysteine residue {C33} MODIFICATION: cysteine residue {C57} cysteine residue {C34} MODIFICATION: cysteine residue {C73} cysteine residue {C49} MODIFICATION: cysteine residue {C91} N-glycosylation site {N52} cysteine residue {C57} MODIFICATION: cysteine residue {C33} cysteine residue {C73} MODIFICATION: cysteine residue {C34} cysteine residue {C91} MODIFICATION: cysteine residue {C49} SECRETED-BY: monocyte T-cell mast cell

References

  1. UniProt :accession P22362
  2. Wikipedia; Note: CCL1 entry http://en.wikipedia.org/wiki/CCL1
  3. Henderson B & Blake S Therapeutic potential of cytokine manipulation TIPS 13:145 1992 PMID: 1589908
  4. Herschman HR Extracellular signals, transcriptional responses and cellular specificity TIBS 14:455 1989 PMID: 2696174

Component-of

molecular complex

Databases & Figures

OMIM 182281 UniProt P22362 Pfam PF00048 Entrez Gene 6346 Kegg hsa:6346 CC ligand and receptor binding