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Izumo sperm-egg fusion protein 1 (sperm-specific protein izumo) (IZUMO1)
Function:
- role in the fertilization process
- role in fusion of sperm with egg
Structure:
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
Compartment: membrane
Alternative splicing: named isoforms=3
Expression:
- sperm-specific (at protein level)
- detectable on sperm surface only after the acrosome reaction Misc: Izumo is the name of a Japanese shrine to marriage
General
glycoprotein
testis-specific protein
Properties
SIZE: MW = 39 kD
entity length = 350 aa
COMPARTMENT: cellular compartment
CELL: unspecified cell type
WITHIN: testis
MOTIF: signal sequence {1-21}
immunoglobulin superfamily domain {161-251}
MOTIF: cysteine residue {C182}
MODIFICATION: cysteine residue {C233}
N-glycosylation site {N204}
cysteine residue {C233}
MODIFICATION: cysteine residue {C182}
transmembrane domain {293-313}
Database Correlations
UniProt Q8IYV9
References
UniProt :accession Q8IYV9