Contents

Search

ITIM-like motif

Immunoreceptor tyrosine-based inhibitory motifs found in cytoplasmic domains of NK cell killer inhibitory receptors. Recruit phosphatases (primarily SHP-1) upon tyrosine phosphorylation.

Related

immunoreceptor tyrosine-based activator motif (ITAM) immunoreceptor tyrosine-based inhibitory motif (ITIM)

General

peptide motif

Properties

MOTIF-SEQUENCE: N/VSxYxxV/L

References

  1. Cosman et al. Immunity 7:273-82, 1997
  2. Meyaard et al. Immunity 7:283-90, 1997