Islet cell autoantigen 1; 69 kD islet cell autoantigen; ICA69; Islet cell autoantigen p69; ICAp69; p69 (ICA1)

Function: - may play a role in neurotransmitter secretion Structure: contains 1 AH domain Compartment: - cytoplasm, cytosol - Golgi membrane - peripheral membrane protein (putative) - cytoplasmic vesicle, secretory vesicle membrane - peripheral membrane protein (putative) - cytoplasmic vesicle, secretory vesicle - synaptic vesicle membrane - predominantly cytosolic - also exists as a membrane-bound form which has been found associated with synaptic vesicles & also with the Golgi complex & immature secretory granules Expression: - expressed abundantly in pancreas, heart & brain with low levels of expression in lung, kidney, liver & thyroid Pathology: - autoantigen in insulin-dependent diabetes mellitus

General

antigen other protein

Properties

SIZE: entity length = 483 aa MW = 55 kD COMPARTMENT: cytoplasm golgi MOTIF: AH {51-254}

Database Correlations

OMIM 147625 UniProt Q05084 PFAM correlations Entrez Gene 3382 Kegg hsa:3382

References

UniProt :accession Q05084