IQ motif & Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100, ADP-ribosylation factors guanine nucleotide-exchange protein 2, brefeldin-resistant Arf-GEF 2 protein, IQSEC1, ARFGEP100, BRAG2, KIAA0763)

Function: - accelerates GTP gamma S binding by ARFs of all 3 classes - guanine nucleotide exchange factor for ARF6 - mediates internalization of beta-1 integrin Structure: - belongs to the BRAG family - contains 1 IQ domain - contains 1 PH domain - contains 1 SEC7 domain Compartment: - cytoplasm, nucleus - at steady state, may be preferentially cytosolic Alternative splicing: named isoforms=2 Expression: - expressed in brain, ovary, heart, lung, liver, kidney, leukocytes > lung, skeletal muscle, placenta, small intestine, pancreas, spleen, testis

General

guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS) phosphoprotein

Properties

SIZE: MW = 108 kD entity length = 963 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: IQ motif {134-163} Thr phosphorylation site {T362} Ser phosphorylation site {S515} sec7 domain SITE: 517-710 PH domain {774-866} coiled coil {848-879}

Database Correlations

UniProt Q6DN90 PFAM correlations

References

UniProt :accession Q6DN90