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inositol 1,4,5 triphosphate [IP3]-3-kinase
Target of tyrosine kinases?
Interactions
molecular events
Specific
inositol 1,4,5 triphosphate [IP3]-3-kinase A (IP3 3-kinase A, IP3K-A, ITPKA)
inositol 1,4,5 triphosphate [IP3]-3-kinase B (IP3 3-kinase B, IP3K-B, ITPKB)
General
calmodulin binding protein
kinase or ATP-phosphotransferase
PEST protein
Properties
SIZE: MW = 53 kD
calculated = 49.85 kD
COMPARTMENT: cytoplasm
CELL: CA1 pyramidal neuron
WITHIN: cornus ammonis [CA]-1
Purkinje cell
WITHIN: cerebellar cortex
dentate granule neuron
WITHIN: dentate gyrus
MOTIF: Ser phosphorylation site {S109}
Ser phosphorylation site {S167}
kinase domain
MOTIF: ATP-binding site
NAME: ATP-binding site
calmodulin binding site
FOR-BINDING-OF: calmodulin
PEST region (6)
References
- Choi JY et al
Molecular clonining and expression of a complementary DNA
for inositol 1,4,5-triphosphate 3-kinase
Science 248:64 1990
PMID: 2157285
- Mailleux P, Takazawa K, Erneux C, Vanderhaeghen JJ.
Inositol 1,4,5-trisphosphate 3-kinase mRNA: high levels in
the rat hippocampal CA1 pyramidal and dentate gyrus granule
cells and in cerebellar Purkinje cells.
J Neurochem. 1991 Jan;56(1):345-7.
PMID: 1846176
- Sim SS, Kim JW, Rhee SG.
Regulation of D-myo-inositol 1,4,5-trisphosphate 3-kinase by
cAMP-dependent protein kinase and protein kinase C.
J Biol Chem. 1990 Jun 25;265(18):10367-72.
PMID: 2162347