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multimer
Function:
- part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia
- cytoskeletal protein cross-linked by transglutaminase
- may be involved in formation of a cytoskeletal cross-linked structure adjacent to the plasma membrane of squamous epithelia [1] & in the formation of apoptotic cell bodies [2]
- some Gln & Lysare cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin & envoplakin, & to lipids like omega-hydroxyceramide
- directly or indirectly cross-linked to cornifelin (CNFN)
Structure: belongs to the involucrin family
Compartment:
- cytoplasm
- constituent of the scaffolding of the cornified envelope
Expression:
- keratinocytes of epidermis & other stratified squamous epithelia
Interactions
molecular events
General
cytoskeletal protein
oligomerizing protein
Properties
SIZE: entity length = 585 aa
MW = 68 kD
COMPARTMENT: cytoplasm
MOTIF: repeat {153-542}
MOTIF: consensus repeat {153-162}
consensus repeat {163-172}
consensus repeat {173-182}
consensus repeat {183-192}
consensus repeat {193-202}
consensus repeat {203-212}
consensus repeat {213-222}
consensus repeat {223-232}
consensus repeat {233-242}
consensus repeat {243-252}
consensus repeat {253-262}
consensus repeat {263-272}
consensus repeat {273-282}
consensus repeat {283-292}
consensus repeat {293-302}
consensus repeat {303-312}
consensus repeat {313-322}
consensus repeat {323-332}
consensus repeat {333-342}
consensus repeat {343-352}
consensus repeat {353-362}
consensus repeat {363-372}
consensus repeat {373-382}
consensus repeat {383-392}
consensus repeat {393-402}
consensus repeat {403-412}
consensus repeat {413-422}
consensus repeat {423-432}
consensus repeat {433-442}
consensus repeat {443-452}
consensus repeat {453-462}
consensus repeat {463-472}
consensus repeat {473-482}
consensus repeat {483-492}
consensus repeat {493-502}
consensus repeat {503-512}
consensus repeat {513-522}
consensus repeat {523-532}
consensus repeat {533-542}
lysine residue (SEVERAL)
glutamine-rich region (10)
MOTIF: glutamine residue (SEVERAL)
lysine residue (SEVERAL)
MODIFICATION: glutamine residue
Database Correlations
OMIM 147360
UniProt P07476
PFAM correlations
Entrez Gene 3713
Kegg hsa:3713
References
- PROSITE :accession PS00795
- Martin SJ, Green DR, Cotter TG.
Dicing with death: dissecting the components of the apoptosis
machinery.
Trends Biochem Sci. 1994 Jan;19(1):26-30. Review.
PMID: 8140617
- UniProt :accession P07476