intravenous anti-emetic combination

Indications: -> relief of nausea/vomiting in palliative care Dosage: (administration) 1) usual rate is 2.7-3.7 mL/hour continuously 2) add 60 mL of normal saline to each formula Formulas* (combinations): 1) metoclopramide (Reglan) 40 mg - prochlorperazine (Compazine) 30 mg - diphenhydramine (Benadryl) 12.5 mg - chlorpromazine (Thorazine) 25 mg - droperidol (Inapsine) 5 mg 2) metoclopramide (Reglan) 40 mg - prochlorperazine (Compazine) 30 mg - chlorpromazine (Thorazine) 25 mg - droperidol (Inapsine) 5 mg 3) metoclopramide (Reglan) 20 mg - diphenhydramine (Benadryl) 12.5 mg - chlorpromazine (Thorazine) 25 mg - droperidol (Inapsine) 5 mg - ranitidine (Zantac) 50 mg 4) metoclopramide (Reglan) 20 mg - diphenhydramine (Benadryl) 100 mg - droperidol (Inapsine) 10 mg - ranitidine (Zantac) 50 mg 5) metoclopramide (Reglan) 30 mg - prochlorperazine (Compazine) 30 mg - diphenhydramine (Benadryl) 75 mg - chlorpromazine (Thorazine) 25 mg - droperidol (Inapsine) 3.75 mg * May add dexamethasone & ranitidine IV every 6 hours

General

anti-emetic pharmacologic combination

References

Frederich M., UCLA Multicampus Program in Geriatrics & Gerontology, Syllabus: The Cutting Edge in Palliative Medicine, 2001

Components

chlorpromazine (Thorazine, Ormazine, Propaphenin, Sonazine, Chloractil) dexamethasone (Decadron, Maxidex, AK-Dex, Ozurdex) diphenhydramine (Benadryl, Alledryl, Allergival) droperidol (Inapsine) metoclopramide (Reglan, Metozolv ODT) prochlorperazine (Compazine, Stemetil, Novamin, Buccastem) ranitidine (Zantac, Gastrosedol)