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trefoil factor 3; intestinal trefoil factor; hITF; polypeptide P1.B; hP1.B (TFF3, ITF, TFI)
Function:
- role in maintenance & repair of the intestinal mucosa
- promotes mobility of epithelial cells in healing processes (motogen)
Structure:
- monomer. homodimer; disulfide-linked
- contains 1 P-type (trefoil) domain
Compartment:
- secreted, extracellular space, extracellular matrix
- apical lamina
Expression:
- expressed in goblet cells of the intestines & colon (at protein level)
- expressed by goblet cells of intestinal epithelia
- expressed in uterus
General
secreted protein
Properties
SIZE: entity length = 80 aa
MW = 9 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
P-type {30-73}
MOTIF: cysteine residue {C32}
MODIFICATION: cysteine residue {C58}
cysteine residue {C42}
MODIFICATION: cysteine residue {C57}
cysteine residue {C52}
MODIFICATION: cysteine residue {C69}
cysteine residue {C57}
MODIFICATION: cysteine residue {C42}
cysteine residue {C58}
MODIFICATION: cysteine residue {C32}
cysteine residue {C69}
MODIFICATION: cysteine residue {C52}
cysteine residue {C78}
MODIFICATION: cysteine residue {C-INTERCHAIN}
Database Correlations
OMIM 600633
UniProt Q07654
Pfam PF00088
Entrez Gene 7033
Kegg hsa:7033
References
- UniProt :accession Q07654
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/TFF3ID265.html