inter-alpha-trypsin inhibitor heavy chain H5 (ITI heavy chain H5, inter-alpha-inhibitor heavy chain 5) (ITIH5 KIAA1953 UNQ311/PRO354)

Function: may act as a tumor suppressor Structure: - belongs to the ITIH family - contains 1 VWFA domain Compartment: secreted (putative) Alternative splicing: named isoforms=3 Expression: - abundantly expressed in placenta - less abundant expression in mammary gland & ovary - expression is barely detectable levels in all other tissues tested Pathology: down-regulated in breast tumors

General

anti-oncoprotein (tumor suppressor protein) glycoprotein secreted protein

Properties

SIZE: entity length = 942 aa MW = 105 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-16} N-glycosylation site {N97} N-glycosylation site {N127} N-glycosylation site {N231} VWFA domain {295-478} MOTIF: N-glycosylation site {N421} N-glycosylation site {N508} N-glycosylation site {N776} N-glycosylation site {N795} N-glycosylation site {N862}

Database Correlations

UniProt Q86UX2 PFAM correlations

References

UniProt :accession Q86UX2