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inter alpha trypsin inhibitor (inter-alpha-inhibitor, I-alpha-I)
Function:
- carrier of hyaluronan in serum (putative)
- binding protein between hyaluronan & other matrix proteins, including those on cell surfaces
- may regulate localization, synthesis & degradation of hyaluronan
Structure:
- subunits:
- ITIH1, ITIH2 & alpha-1 microglobulin (bikunin)
- ITIH2 linked to bikunin via chondroitin 4-sulfate esterified to the ITIH2 alpha-carboxyl of C-terminal Asp after propeptide cleavage (putative)
General
inter alpha globulin
molecular complex
trypsin inhibitor
Properties
COMPARTMENT: plasma
MOTIF: serpin motif
FOR-BINDING-OF: serine protease
INHIBITS: trypsin
SUBUNITS: inter alpha antitrypsin heavy chain
MOTIF: Kunitz-type serine protease inhibitor [KPI] domain (2)
MOTIF: cysteine residue {X+0}
MODIFICATION: cysteine residue {X+X5}
cysteine residue {X+X1}
MODIFICATION: cysteine residue {X+X3}
cysteine residue {X+X2}
MODIFICATION: cysteine residue {X+X4}
cysteine residue {X+X3}
MODIFICATION: cysteine residue {X+X1}
cysteine residue {X+X4}
MODIFICATION: cysteine residue {X+X2}
cysteine residue {X+X5}
MODIFICATION: cysteine residue {X+0}
FOR-BINDING-OF: serine protease
alpha-1 microglobulin
MOTIF: signal sequence {1-19}
Thr glycosylation site {T24}
N-glycosylation site {N36}
cysteine residue {C91}
MODIFICATION: cysteine residue {C188}
N-glycosylation site {N115}
cysteine residue {C188}
MODIFICATION: cysteine residue {C91}
GLYCOPEPTIDE (SECRETORY) {206-226}
MOTIF: Ser glycosylation site {S215}
Kunitz-type serine protease inhibitor [KPI] domain {231-337} (2)
MOTIF: cysteine residue {C231}
MODIFICATION: cysteine residue {C281}
cysteine residue {C240}
MODIFICATION: cysteine residue {C264}
N-glycosylation site {N250}
cysteine residue {C256}
MODIFICATION: cysteine residue {C277}
cysteine residue {C264}
MODIFICATION: cysteine residue {C240}
cysteine residue {C277}
MODIFICATION: cysteine residue {C256}
cysteine residue {C281}
MODIFICATION: cysteine residue {C231}
FOR-BINDING-OF: serine protease
References
- Tietz Fundamentals of Clinical Chemistry 3rd ed, WB
Saunders, 1987 pg 335
- UniProt :accession P19823
Components
alpha-1 microglobulin; alpha-1 antitrypsin light chain; protein HC; bikunin (a lipocalin, AMBP, HCP, ITIL)
inter alpha antitrypsin heavy chain