inter alpha antitrypsin heavy chain-4 (ITI heavy chain H4, inter-alpha-inhibitor heavy chain 4, inter-alpha-trypsin inhibitor family heavy chain-related protein, IHRP, plasma kallikrein sensitive glycoprotein 120, PK-120, GP120, ITIH4, IHRP, ITIHL1, PK120, PRO1851)

Function: 1) involved in acute phase reactions 2) levels increase significantly in sera of patients after surgical trauma 3) cleaved by plasma kallikrein to yield 100 kD & 35 kD fragments - 100 kD fragment is further converted to 70 kD fragment Structure: - belongs to the ITIH family - contains 1 VWFA domain - appears to be both N- & O-glycosylated - O-linked polysaccharides on Ser-696, Thr-701 & Ser-702 are probably the mucin type linked to galNAc Compartment: secreted Alternative splicing: named isoforms=2 Expression: liver specific Pathology: - levels increase significantly in the sera of patients after different surgical trauma

General

glycoprotein inter alpha antitrypsin heavy chain

Properties

SIZE: MW = 103 kD entity length = 930 aa MOTIF: signal sequence {1-28} N-glycosylation site {N81} N-glycosylation site {N207} VWFA domain {272-432} N-glycosylation site {N517} N-glycosylation site {N577} Ser glycosylation site {S696} Thr glycosylation site {T701} Ser glycosylation site {S702} cysteine residue {C747} MODIFICATION: cysteine residue {C925} cysteine residue {C925} MODIFICATION: cysteine residue {C747}

Database Correlations

OMIM 600564 UniProt Q14624

References

UniProt :accession Q14624