inter alpha antitrypsin heavy chain-3 (ITIH3, ITI heavy chain H3, inter-alpha-inhibitor heavy chain 3, serum-derived hyaluronan-associated protein, SHAP)

Function: 1) component of pre-alpha-inhibitor (P-alpha-I) 2) carrier of hyaluronan in serum or binding protein between hyaluronate & other matrix protein(s) 3) contains a potential peptide potentially stimulating phagocytotic cells Structure: - belongs to the ITIH family - contains 1 VWFA domain - linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage (putative) Compartment: secreted Alternative splicing: named isoforms=2

General

glycoprotein inter alpha antitrypsin heavy chain

Properties

SIZE: MW = 99 kD entity length = 885 aa MOTIF: signal sequence {1-17} N-glycosylation site {N87} VWFA domain {278-438} N-glycosylation site {N576} binding site SITE: 647-647 FOR-BINDING-OF: chondroitin sulfate

Database Correlations

OMIM 146650 UniProt Q06033 PFAM correlations

References

Uniprot :accession Q06033