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inter alpha antitrypsin heavy chain-1 (inter-alpha-trypsin inhibitor heavy chain H1 precursor, ITI heavy chain H1, inter-alpha-trypsin inhibitor complex component 3, serum-derived hyaluronan-associated protein, SHAP, ITIH1, IGHEP1)
Function:
1) component of I-alpha-I
2) carrier of hyaluronan in serum or binding protein between hyaluronate & other matrix protein(s)
3) contains a potential peptide potentially stimulating phagocytotic cells
Structure:
- belongs to the ITIH family
- contains 1 VWFA domain
- S-linked glycan is composed of two units of either Glc or Gal
- Mass Spectroscopy: mass=76258; method=MALDI; Range=28-672
Compartment: secreted
Polymorphism: 3 common alleles
General
glycoprotein
inter alpha antitrypsin heavy chain
Properties
SIZE: MW = 101 kD
entity length = 911 aa
MOTIF: signal sequence {1-27}
cysteine residue {C244}
MODIFICATION: cysteine residue {C247}
cysteine residue {C247}
MODIFICATION: cysteine residue {C244}
cysteine residue {C268}
MODIFICATION: cysteine residue {C540}
N-glycosylation site {N285}
VWFA domain {290-450}
binding site
SITE: 387-911
FOR-BINDING-OF: hyaluronate
MOTIF: cysteine residue {C540}
MODIFICATION: cysteine residue {C268}
N-glycosylation site {N588}
Thr glycosylation site {T653}
binding site
SITE: 672-672
FOR-BINDING-OF: chondroitin sulfate
Database Correlations
OMIM 147270
UniProt P19827
PFAM correlations
Kegg hsa:3697
References
- UniProt :accession P19827
- OMIM :accession 147270
- Mass Spectroscopy
PMID: 9677337