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retinol-binding protein 3; interphotoreceptor retinoid-binding protein; IRBP; interstitial retinol-binding protein (RBP3)
Function:
- IRBP shuttles 11-cis & all trans retinoids between the retinol isomerase in the pigment epithelium & the visual pigments in the retinal photoreceptor cells
Structure: belongs to the peptidase S41A family
Compartment:
- secreted into the interphotoreceptor matrix permeating the space between the retina & contiguous layer of pigment epithelium
Note:
- uncertain whether Met-1 or Met-2 is the initiator
General
lipocalin
retinol binding protein
secreted protein
Properties
SIZE: entity length = 1247 aa
MW = 135 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-17}
4 X approximate tandem repeats {18-1230}
MOTIF: consensus repeat {18-320}
N-glycosylation site {N205}
consensus repeat {321-630}
N-glycosylation site {N515}
consensus repeat {631-931}
consensus repeat {932-1230}
Database Correlations
OMIM 180290
UniProt P10745
PFAM correlations
Entrez Gene 5949
Kegg hsa:5949
References
- UniProt :accession P10745
- OMIM :accession 180290