interstitial neuron

Cellular remnant of the embryonic subplate within the subcortical white matter. Interstitial cells are especially abundant in white matter entorhinal & transentorhinal cortex. There they form a somewhat ill-defined layer (profound layer) through which the perforant pathway passes. These interstitial neurons exhibit extensive dendritic arborization perpendicular to the axons of the perforant pathway. They may show somatostatin reactivity. Pathology: - interstitial neurons in white matter adjacent to the entorhinal & transentorhinal cortex are susceptible to formation of paired helical filaments in Alzheimer's disease

References

- van de Nes JA, Sandmann-Keil D, Braak H. Interstitial cells subjacent to the entorhinal region expressing somatostatin-28 immunoreactivity are susceptible to development of Alzheimer's disease-related cytoskeletal changes. Acta Neuropathol (Berl). 2002 Oct;104(4):351-6. Epub 2002 May 22. PMID: 12200620