Search
intersectin-2 (SH3 domain-containing protein 1B, SH3P18, SH3P18-like WASP-associated protein, ITSN2, KIAA1256, SH3D1B, SWAP)
Function:
1) adapter protein
2) indirect link between endocytic membrane traffic & actin assembly (putative)
3) regulates formation of clathrin-coated vesicles
4) component of complex that may contain multimers of ITSN1, ITSN2, EPS15
5) overexpression inhibits transferrin uptake & blocks clathrin-mediated endocytosis
Compartment: cytoplasm
Alternative splicing: named isoforms=4
Expression:
- ubiquitous
- isoform 1 is primarily expressed in adult heart & liver
General
Ca+2 binding protein
cytoskeletal protein
phosphoprotein
Properties
SIZE: MW = 193 kD
entity length = 1696 aa
COMPARTMENT: cytoplasm
MOTIF: EH 1 {21-109}
MOTIF: EF hand
SITE: 53-88
EH 2 {243-332}
coiled coil {360-755}
src homology 3 [SH3] domain
SITE: 756-817
Tyr phosphorylation site {Y858}
src homology 3 [SH3] domain
SITE: 897-955
Tyr phosphorylation site {Y967}
src homology 3 [SH3] domain
SITE: 980-1038
src homology 3 [SH3] domain
SITE: 1052-1116
src homology 3 [SH3] domain
SITE: 1126-1185
Dbl homology domain {1208-1394}
PH domain {1433-1543}
C2 domain {1555-1651}
MOTIF: binding site
FOR-BINDING-OF: phospholipid
Ca+2-binding site
Database Correlations
OMIM 604464
UniProt Q9NZM3
PFAM correlations
References
UniProt :accession Q9NZM3