interphotoreceptor matrix proteoglycan 1 (interphotoreceptor matrix proteoglycan of 150 kD, IPM-150, sialoprotein associated with cones & rods, IMPG1, IPM150, SPACR)

Function: - interacts with hyaluronan to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix (putative) Structure: 1 N-terminus is blocked 2) highly glycosylated (N- & O-linked carbohydrates & sialic acid) 3) contains 2 SEA domains Compartment: extacellular matrix (interphotoreceptor matrix of retina) Expression: - expressed in retina - specifically expressed by cone & rod photoreceptor cells - localizes to cone & rod photoreceptor cells surrounding the interphotoreceptor matrix of the retina

General

matrix protein sialoglycoprotein

Properties

SIZE: MW = 89 kD entity length = 797 aa COMPARTMENT: extracellular matrix MOTIF: signal sequence {1-20} N-glycosylation site {N42} N-glycosylation site {N143} N-glycosylation site {N191} N-glycosylation site {N215} SEA domain {230-345} Thr glycosylation site {T403} Thr glycosylation site {T421} Thr glycosylation site {T432} Thr glycosylation site {T442} SEA domain {567-685} MOTIF: N-glycosylation site {N592} N-glycosylation site {N616} N-glycosylation site {N630} N-glycosylation site {N648}

Database Correlations

OMIM 602870 UniProt Q17R60 Pfam PF01390

References

UniProt :accession Q17R60