intermediate filament protein-3 (peripherin)

Function: - peripherin can self-assemble or co-assemble with neurofilaments to form intermediate filaments Expression: - expressed predominantly in peripheral nervous system - also expressed in central nervous system: - spinal motor neurons - sensory cranial nerve nuclei - small interneurons Note: - the major intermediate filament protein in PC12 cells

General

intermediate filament protein phosphoprotein

Properties

SIZE: MW = 58 kD COMPARTMENT: cytoplasm CELL: PC12 cell ORGANISM: Rattus (rat) MOTIF: O-glycosylation site {N-TERMINAL} rod-like {central-region} MOTIF: alpha helix coiled coil S/T phosphorylation site

Database Correlations

OMIM 170710 MORBIDMAP 170710 UniProt P41219

References

Cairns NJ, Lee VM, Trojanowski JQ. The cytoskeleton in neurodegenerative diseases. J Pathol. 2004 Nov;204(4):438-49. Review. PMID: 15495240