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intermediate filament protein
5 intermediate filament proteins are expressed in the human adult CNS:
- neurofilament proteins L, M, H
- peripherin
- alpha-internexin
Specific
desmin (DES)
glial fibrillary acidic protein; GFAP (GFAP)
intermediate filament protein syncoilin
intermediate filament protein-3 (peripherin)
intermediate filament tail domain-containing protein 1 (IFLTD1)
keratin
lamin or nuclear lamin
nestin (NES)
neurofilament protein
periferin
plasticin
syncoilin-1; syncoilin intermediate filament 1 (SYNC1, SYNC)
synemin; desmuslin (SYNM, DMN, KIAA0353, SYN)
vimentin (VIM)
General
cytoskeletal protein
filamentous protein
Properties
COMPARTMENT: cytoplasm
MOTIF: O-glycosylation site {N-TERMINAL}
rod-like {central-region}
MOTIF: alpha helix
coiled coil
glutamate-rich region {C-TERMINAL}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site (SEVERAL)
MOTIF-SEQUENCE: KSP
References
- Cairns NJ, Lee VM, Trojanowski JQ.
The cytoskeleton in neurodegenerative diseases.
J Pathol. 2004 Nov;204(4):438-49. Review.
PMID: 15495240
- Omary MB, Coulombe PA, McLean WH.
Intermediate filament proteins and their associated diseases.
N Engl J Med. 2004 Nov 11;351(20):2087-100. Review.
PMID: 15537907
Component-of
intermediate filament