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interleukin enhancer-binding factor 2; nuclear factor of activated T-cells 45 kD (ILF2, NF45, PRO3063)
Function:
1) heterodimeric complex with ILF3
2) complex may regulate transcription of the IL2 gene during T-cell activation
3) formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA
4) phosphorylated upon DNA damage, probably by ATM or ATR
Structure: contains 1 DZF domain
Compartment: nucleus, nucleolus
Related
interleukin enhancer-binding factor 3; nuclear factor of activated T-cells 90 kD; NF-AT-90; double-stranded RNA-binding protein 76; DRBP76; translational control protein 80; TCP80; nuclear factor associated with dsRNA; NFAR; M-phase phosphoprotein 4 (ILF3, MPP4, DRBF, MPHOSPH4, NF90)
General
interleukin enhancer binding factor
phosphoprotein
Properties
SIZE: entity length = 390 aa
MW = 43 kD
COMPARTMENT: cell nucleus
MOTIF: DZF {104-338}
glutamate-rich region {366-372}
MOTIF: glutamate residue (SEVERAL)
glutamate-rich region {381-384}
MOTIF: glutamate residue (SEVERAL)
Thr phosphorylation site {T388}
Database Correlations
OMIM 603181
UniProt Q12905
Pfam PF07528
Kegg hsa:3608
References
- UniProt :accession Q12905
- Entrez Gene :accession 3608
Component-of
mRNP granule complex