Search
forkhead box protein K2; interleukin enhancer-binding factor 1; cellular transcription factor ILF-1 (FOXK1, FOXK2 ILF ILF1)
Function:
- recognizes the core sequence 5'-TAAACA-3'
- binds to NFAT-like motifs (purine-rich) in IL2 promoter
- also binds to HIV-1 long terminal repeat
- may be involved in both positive & negative regulation of viral & cellular promoter elements
- phosphorylated upon DNA damage, probably by ATM or ATR
Cofactor: binds 1 Mg+2 per subunit
Structure:
- C-terminal part of the DNA-binding domain may contribute to DNA recognition specificity
- contains 1 FHA domain
- contains 1 fork-head DNA-binding domain
Compartment: nucleus (probable)
Alternative splicing: named isoforms=3
Expression:
- expressed in both lymphoid & non-lymphoid cells
General
forkhead family transcription factor
interleukin enhancer binding factor
phosphoprotein
Properties
SIZE: entity length = 660 aa
MW = 69 kD
COMPARTMENT: cell nucleus
MOTIF: glycine-rich region {10-93}
forkhead-associated (FHA) domain {54-128}
MOTIF: Ser phosphorylation site {S61}
Ser phosphorylation site {S239}
fork head domain
NAME: fork head domain
SITE: 258-353
MOTIF: binding site
SITE: 300-318
FOR-BINDING-OF: deoxyribonucleic acid (DNA)
Mg+2-binding site
SITE: 310-310
Mg+2-binding site
SITE: 311-311
Mg+2-binding site
SITE: 313-313
Mg+2-binding site
SITE: 316-316
binding site
SITE: 328-332
FOR-BINDING-OF: deoxyribonucleic acid (DNA)
binding site
SITE: 348-353
FOR-BINDING-OF: deoxyribonucleic acid (DNA)
Ser phosphorylation site {S398}
Ser phosphorylation site {S428}
Database Correlations
OMIM 147685
UniProt Q01167
PFAM correlations
Entrez Gene 3607
Kegg hsa:3607
References
- UniProt :accession Q01167
- Entrez Gene :accession 3607