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interleukin-5; IL-5; B-cell differentiation factor 1; eosinophil differentiation factor; T-cell replacing factor; TRF (IL5)
Function:
- induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells
Structure:
- homodimer, disulfide-linked
- belongs to the IL-5 family
Compartment: secreted
Related
interleukin-5 receptor (IL5 receptor)
General
interleukin
molecular complex
Properties
SIZE: entity length = 134 aa
MW = 15 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-19}
Thr glycosylation site {T22}
N-glycosylation site {N47}
cysteine residue {C63}
MODIFICATION: cysteine residue {C105}
asparagine residue {90}
cysteine residue {C105}
MODIFICATION: cysteine residue {C63}
SECRETED-BY: T helper 2 cell
mast cell
Database Correlations
OMIM 147850
UniProt P05113
Pfam PF02025
Entrez Gene 3567
Kegg hsa:3567
References
- UniProt :accession P05113
- R&D systems' cytokine mini-reviews: IL-5
http://www.rndsystems.com/molecule_detail.aspx?m=1646
- Wikipedia; Note: interleukin-5 entry
http://en.wikipedia.org/wiki/interleukin_5
- SeattleSNPs
http://pga.gs.washington.edu/data/il5/
- Henderson B & Blake S
Therapeutic potential of cytokine manipulation
TIPS 13:145 1992
PMID: 1589908
- Scott P
IL-12: initiation cytokine for cell-mediated immunity
Science 260:496 1993
PMID: 8097337 (secretion)
- Milburn et al,
A novel dimer configuration revealed by crystal structure at
2.4 A resolution of human interleukin-5.
Nature 363:172 1993 (crystal)
PMID: 8483502