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interleukin-4 induced protein 1; L-amino-acid oxidase; LAAO; LAO; IL4-induced protein 1; protein Fig-1; hFIG1 (IL4I1, FIG1, UNQ636/PRO1265)

Function: - lysosomal L-amino-acid oxidase - highest specific activity with phenylalanine - may play a role in lysosomal antigen processing & presentation L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2 Cofactor: FAD (putative) Structure: - belongs to the flavin monoamine oxidase family, FIG1 subfamily Compartment: - isoform 1: lysosome (putative) - isoform 2: lysosome (putative) Alternative promoter usage: - uses the promoter of the upstream NUP62 gene & shares the first 2 non-coding exons with NUP62 Alternative splicing: named isoforms=2 Expression: - isoform 1 is primarily found in immune tissues - induced by IL4/interleukin-4 Pathology: - IL4I1 may diminish inflammation & enhance re-myelination in multiple sclerosis [2]

Related

interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; binetrakin; lymphocyte stimulatory factor 1; pitrakinra (IL4)

General

flavoprotein glycoprotein

Properties

SIZE: entity length = 567 aa MW = 63 kD COMPARTMENT: lysosome MOTIF: signal sequence {1-21} cysteine residue {C36} MODIFICATION: cysteine residue {C199} N-glycosylation site {N54} binding site SITE: 89-89 FOR-BINDING-OF: FAD binding site SITE: 97-97 FOR-BINDING-OF: FAD cofactor-binding site [115-116] COFACTOR-BOUND: flavin adenine dinucleotide MOTIF: binding site SITE: 116-116 FOR-BINDING-OF: Substrate N-glycosylation site {N134} cysteine residue {C199} MODIFICATION: cysteine residue {C36} N-glycosylation site {N220} binding site SITE: 287-287 FOR-BINDING-OF: FAD; via amide nitrogen and carbonyl oxygen binding site SITE: 398-398 FOR-BINDING-OF: Substrate binding site SITE: 481-481 FOR-BINDING-OF: FAD cofactor-binding site [490-493] COFACTOR-BOUND: flavin adenine dinucleotide N-glycosylation site {N559}

Database Correlations

OMIM 609742 UniProt Q96RQ9 Pfam PF01593 Entrez Gene 259307 Kegg hsa:259307 ENZYME 1.4.3.2

References

  1. UniProt :accession Q96RQ9
  2. Fiore K. Protein May Be Marker of MS Disease Severity, Remyelination - Early work suggests beneficial effect of IL4I1 in multiple sclerosis. MedPage Today. Nov 13, 2017 https://www.medpagetoday.com/meetingcoverage/sfn/69252 - Davis S, et al Interleukin-4 induced protein 1 as a biomarker and treatment option in multiple sclerosis. Society for Neuroscience (SfN) 2017; Abstract 304.08/X30