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interleukin-3; erythrocyte burst-promoting factor; hematopoietic growth factor; mast-cell colony-stimulating factor; multipotential colony-stimulating factor; colony-stimulating factor-2 alpha; mast cell growth factor; P-cell stimulating factor (IL3, IL-3)
Function:
- granulocyte/macrophage colony-stimulating factor
- induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils & megakaryocytes
- IL-3 may preferentially participate in expansion of hematopoietic cells in response to inflammatory stimuli rather than constititive hematopoiesis [1]
- predominant growth factor for erythroblast proliferation [2]
Structure:
- monomer
- belongs to the IL-3 family
Compartment: secreted
Expression:
- activated T-cells, mast cells, natural killer cells
Related
interleukin-3 receptor (IL3 receptor)
General
colony-stimulating factor (CSF)
glycoprotein
interleukin
Properties
SIZE: MW = 20-30 kD
entity length = 133-140 aa
COMPARTMENT: extracellular compartment
MOTIF: N-glycosylation site {N34}
cysteine residue {C35}
MODIFICATION: cysteine residue {C103}
N-glycosylation site {N89}
cysteine residue {C103}
MODIFICATION: cysteine residue {C35}
binding site
FOR-BINDING-OF: heparan sulfate
SECRETED-BY: T-cell
keratinocyte
WITHIN: epidermis
mast cell
Database Correlations
OMIM 147740
UniProt P08700
Pfam PF02059
Entrez Gene 3562
Kegg hsa:3562
References
- UniProt :accession P08700
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/IL3ID60.html
- SeattleSNPs
http://pga.gs.washington.edu/data/il3/
- Henderson B & Blake S
Therapeutic potential of cytokine manipulation
TIPS 13:145 1992
PMID: 1589908
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998
- Entrez Gene :accession 3562