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interleukin-29; IL-29; cytokine Zcyto21; interferon lambda-1; IFN-lambda-1 (IL29, IFNL1, ZCYTO21)
Function:
1) cytokine with immunomodulatory activity
2) antiviral immunity
3) up-regulates MHC class I antigen expression
4) ligand for the heterodimeric class II cytokine receptor IL10RB/IL28RA
5) signals through the Jak-STAT pathway.
Compartment: secreted
Expression: induction by viral infections or dsRNA.
General
glycoprotein
interferon [IFN]-lambda (IFNL)
interleukin
Properties
SIZE: entity length = 200 aa
MW = 22 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-19}
N-glycosylation site {N65}
cysteine residue {C68}
MODIFICATION: cysteine residue {C164}
cysteine residue {C164}
MODIFICATION: cysteine residue {C68}
Database Correlations
OMIM 607403
UniProt Q8IU54
Entrez Gene 282618
Kegg hsa:282618
References
- Entrez Gene :accession 282618
- UniProt :accession Q9UBU7
- Wikipedia; Note: interleukin-29 entry
http://en.wikipedia.org/wiki/interleukin_29