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interleukin-28 receptor alpha chain; IL-28R-alpha; IL-28RA; cytokine receptor class-II member 12; cytokine receptor family 2 member 12; CRF2-12; interferon lambda receptor 1; IFN-lambda R1; likely interleukin or cytokine receptor 2 (IL28RA IFNLR1 LICR2)
Function:
1) IL28RA/IL10RB dimer is a receptor for IL28A, IL28B & IL29
2) signal through Jak-STAT pathway (putative)
Structure:
- belongs to the type II cytokine receptor family
- contains 1 fibronectin F3 module
Compartment: membrane
Alternative splicing: named isoforms=4
Expression: widely expressed.
General
glycoprotein
membrane protein
protein subunit
Properties
SIZE: MW = 58 kD
entity length = 520 aa
MOTIF: signal sequence {1-20}
fibronectin type III domain or F3 module {23-120}
MOTIF: N-glycosylation site {N29}
N-glycosylation site {N36}
cysteine residue {C74}
MODIFICATION: cysteine residue {C82}
cysteine residue {C82}
MODIFICATION: cysteine residue {C74}
N-glycosylation site {N142}
N-glycosylation site {N169}
transmembrane domain {229-249}
Database Correlations
OMIM 607404
UniProt Q8IU57
Entrez Gene 163702
Kegg hsa:1637
References
- Entrez Gene :accession 163702
- UniProt :accession Q8IU57
Component-of
interleukin-28 receptor (IL28 receptor)