interleukin-27 receptor subunit alpha; IL-27R-alpha; WSX-1; type I T-cell cytokine receptor; TCCR; protein CRL1 (IL27RA, CRL1, TCCR, WSX1, UNQ296/PRO336)

Function: 1) ligand-binding subunit for IL27 receptor 2) requires IL6ST (gp130) to mediate signal transduction in response to IL27 3) acts through STAT3 & STAT1 4) regulation of Th1-type immune response 5) innate defense mechanisms Structure: - WSXWS motif necessary for protein folding - box 1 motif is required for JAK interaction - belongs to the type I cytokine receptor family, type 2 subfamily - contains 3 fibronectin F3 modules Compartment: membrane Expression: - expressed in lymphoid tissues, spleen, lymph nodes, peripheral blood leukocytes > heart, brain, fetal & adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney, colon - in the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets - weaker expression in CD19+ B-cells & monocytes

General

glycoprotein protein subunit

Properties

SIZE: MW = 69 kD entity length = 636 aa MOTIF: signal sequence {1-32} N-glycosylation site {N51} N-glycosylation site {N76} fibronectin type III domain or F3 module {135-228} MOTIF: WSXWS motif {217-221} N-glycosylation site {N302} N-glycosylation site {N311} fibronectin type III domain or F3 module {319-411} MOTIF: N-glycosylation site {N374} N-glycosylation site {N382} fibronectin type III domain or F3 module {416-507} MOTIF: N-glycosylation site {N467} transmembrane domain {517-537} box1 motif SITE: 554-562 FOR-BINDING-OF: Janus kinase (JAK)

Database Correlations

OMIM 605350 UniProt Q6UWB1 Pfam PF00041 Kegg hsa:9466

References

UniProt :accession Q6UWB1