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interleukin-24; IL-24; melanoma differentiation-associated gene 7 protein; MDA-7; suppression of tumorigenicity 16 protein (IL24, MDA7, ST16)
Function:
1) antiproliferative in human melanoma cells
2) terminal cell differentiation (putative)
3) negative regulator of melanoma progression (putative)
4) induces apoptosis in human breast cancer cells
Structure: belongs to the IL-10 family
Compartment: secreted
Alternative splicing: named isoforms=3
Pathology:
- up-regulated in melonoma cells induced to terminally differentiate
General
glycoprotein
interleukin
Properties
SIZE: entity length = 206 aa
MW = 24 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-51}
N-glycosylation site {N85}
N-glycosylation site {N99}
N-glycosylation site {N126}
Database Correlations
OMIM 604136
UniProt Q13007
Entrez Gene 11009
Kegg hsa:11009
References
- Entrez Gene :accession 11009
- UniProt :accession 11009
- Wikipedia; Note: interleukin-24 entry
http://en.wikipedia.org/wiki/interleukin_24
- SeattleSNPs
http://pga.gs.washington.edu/data/il24/