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interleukin-22 receptor alpha-2; IL-22R-alpha-2; interleukin-22-binding protein; IL22BP; cytokine receptor family class II member 10; CRF2-10; cytokine receptor family type 2, soluble 1; CRF2-S1 (IL22RA2)

Function: 1) isoform 2 is a receptor for IL-22 2) binds to IL-22 3) prevents interaction with the functional IL-22R complex 4) blocks activity of IL-22 5) IL-22 antagonist in the regulation of inflammatory responses (putative) 6) isoform 1 may play a role in establishing & maintaining successful pregnancy Structure: belongs to the type II cytokine receptor family Compartment: secreted Alternative splicing: named isoforms=3 Expression: - expressed in placenta, spleen, breast, skin, lung, intestinal tract, testis, brain, heart, thymus - soform 1 is expressed only in placenta - isoform 2 is expressed in placenta, breast > spleen, skin, thymus, stomach

Related

interleukin-22 [IL-22] receptor alpha 1 (IL-22R-alpha-1, cytokine receptor family 2 member 9, CRF2-9, IL22RA1, IL22R)

General

secreted protein

Properties

SIZE: MW = 31 kD entity length = 263 aa COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-21} fibronectin type III domain or F3 module {26-68} MOTIF: N-glycosylation site {N56} fibronectin type III domain or F3 module {100-161} fibronectin type III domain or F3 module {162-263} MOTIF: cysteine residue {C238} MODIFICATION: cysteine residue {C259} cysteine residue {C259} MODIFICATION: cysteine residue {C238}

Database Correlations

OMIM 606648 UniProt Q969J5 Entrez Gene 116379 Kegg hsa:1163

References

  1. Entrez Gene :accession 116379
  2. UniProt :accession Q969J5
  3. SeattleSNPs http://pga.gs.washington.edu/data/il22ra2/