interleukin-22 [IL-22] receptor alpha 1 (IL-22R-alpha-1, cytokine receptor family 2 member 9, CRF2-9, IL22RA1, IL22R)

Function: - component of the receptor for IL20, IL22 & IL24 - component of IL22 receptor formed by IL22RA1 & IL10RB enabling IL22 signaling via JAK/STAT pathways - IL22 also induces activation of MAPK1/MAPK3 & Akt kinases pathways - component of receptor for IL20 & IL24 formed by IL22RA1 & IL20RB also signaling through STATs activation - mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation & differentiation - heterodimer with IL10RB & with IL20RB - IL22 binding to heterodimer is greater than binding to IL22RA1 alone Structure: - belongs to the type II cytokine receptor family - contains 2 fibronectin F3 modules Compartment: membrane Expression: - expressed in colon, liver, lung, pancreas & kidney - no expression in immune cells such as monocytes, T-cells, & NK-cells - expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions - induced by interferon-gamma in keratinocytes Pathology: - strongly expressed on central nervous system vessels within inflitrated multiple sclerosis lesions - overexpressed in synovial fluid cells from rheumatoid arthritis & spondyloarthropathy patients - failure of medical & surgical therapy in chronic rhinosinusitis with nasal polyps is associated with decreased expression of IL22RA1

General

membrane protein protein subunit

Properties

SIZE: entity length = 574 aa MW = 63 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-15} fibronectin type III domain or F3 module {18-115} MOTIF: N-glycosylation site {N80} fibronectin type III domain or F3 module {141-221} MOTIF: N-glycosylation site {N172} transmembrane domain {229-249}

Database Correlations

OMIM 605457 UniProt Q8N6P7 Entrez Gene 58985 Kegg hsa:5898

References

UniProt :accession Q8N6P7