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interleukin-21 receptor; IL-21R; novel interleukin receptor (IL21R, NILR, UNQ3121/PRO10273)
Function:
- receptor for interleukin-21
- heterodimer with the common gamma chain.
- associates with JAK1
Structure:
- the WSXWS motif appears to be necessary for proper protein folding, efficient intracellular transport & cell- surface receptor binding
- the box 1 motif is required for JAK interaction &/or activation
- belongs to the type I cytokine receptor family, type 4 subfamily
- contains 1 fibronectin F3 module
Compartment: membrane
Expression:
- selectively expressed in lymphoid tissues
- most highly expressed in thymus & spleen
General
glycoprotein
interleukin receptor
Properties
SIZE: entity length = 538 aa
MW = 59 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-19}
cysteine residue {C25}
MODIFICATION: cysteine residue {C35}
cysteine residue {C35}
MODIFICATION: cysteine residue {C25}
cysteine residue {C65}
MODIFICATION: cysteine residue {C81}
N-glycosylation site {N73}
cysteine residue {C81}
MODIFICATION: cysteine residue {C65}
N-glycosylation site {N97}
N-glycosylation site {N104}
fibronectin type III domain or F3 module {120-209}
MOTIF: N-glycosylation site {N125}
N-glycosylation site {N135}
WSXWS motif {214-218}
transmembrane domain {233-253}
box1 motif
SITE: 266-274
FOR-BINDING-OF: Janus kinase (JAK)
Database Correlations
OMIM 605383
UniProt Q9HBE5
Entrez Gene 50615
Kegg hsa:5061
References
- UniProt :accession Q9HBE5
- SeattleSNPs
http://pga.gs.washington.edu/data/il21r/