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interleukin-21; IL-21; Za11 (IL21)
Function:
1) cytokine with immunoregulatory activity
2) transition between innate & adaptive immunity (putative)
3) induces synthesis of IgG1 and IgG3 in B-cells
4) proliferation & maturation of natural killer (NK) cells in synergy with IL15 (putative)
5) proliferation of mature B-cells & T-cells
6) synergy with IL15 & IL18
7) stimulates IFN-gamma production in T-cells & NK cells
8) inhibition of dendritic cells activation during T-cell mediated immune response (putative)
Structure: belongs to the IL-15/IL-21 family
Compartment: secreted
Expression:
- expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes
General
glycoprotein
interleukin
Properties
SIZE: entity length = 155 aa
MW = 18 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-22}
cysteine residue {C64}
MODIFICATION: cysteine residue {C115}
cysteine residue {C71}
MODIFICATION: cysteine residue {C118}
N-glycosylation site {N90}
cysteine residue {C115}
MODIFICATION: cysteine residue {C64}
cysteine residue {C118}
MODIFICATION: cysteine residue {C71}
Database Correlations
OMIM 605384
UniProt Q9HBE4
Pfam PF02372
Entrez Gene 59067
Kegg hsa:59067
References
- Entrez Gene :accession 59067
- UniProt :accession Q9HBE4
- SeattleSNPs
http://pga.gs.washington.edu/data/il21/