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interleukin-20 receptor alpha chain; IL-20R-alpha; IL-20R1; cytokine receptor class-II member 8; cytokine receptor family 2 member 8; CRF2-8; ZcytoR7 (IL20RA, ZCYTOR7, UNQ681/PRO1315)
Function:
1) IL20RA/IL20RB dimer is a receptor for IL19, IL20 & IL24
2) IL20RA/IL10RB dimer is a receptor for IL26
Structure:
- belongs to the type II cytokine receptor family
- contains 2 fibronectin F3 modules
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- widely expressed
- highest levels in skin & testis
- high levels in brain
Pathology: highly expressed in psoriatic skin
General
glycoprotein
membrane protein
protein subunit
Properties
SIZE: MW = 63 kD
entity length = 553 aa
MOTIF: signal sequence {1-29}
fibronectin type III domain or F3 module {37-136}
MOTIF: N-glycosylation site {N42}
N-glycosylation site {N83}
cysteine residue {C87}
MODIFICATION: cysteine residue {C95}
N-glycosylation site {N91}
cysteine residue {C95}
MODIFICATION: cysteine residue {C87}
fibronectin type III domain or F3 module {138-237}
MOTIF: N-glycosylation site {N182}
N-glycosylation site {N191}
N-glycosylation site {N200}
cysteine residue {C215}
MODIFICATION: cysteine residue {C236}
cysteine residue {C236}
MODIFICATION: cysteine residue {C215}
transmembrane domain {251-271}
glutamate-rich region {353-356}
MOTIF: glutamate residue (SEVERAL)
Database Correlations
OMIM 605620
UniProt Q9UHF4
Pfam PF01108
Entrez Gene 53832
Kegg hsa:5383
References
- Entrez Gene :accession 53832
- UniProt :accession Q9UHF4
Component-of
interleukin-20 receptor (IL20R, IL19R, IL24R)