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interleukin-1 receptor-like 2; IL-1Rrp2; interleukin-1 receptor-related protein 2; IL1R-rp2 (IL1RL2, IL1RRP2)

Function: 1) receptor for interleukin 1 family member 9 (IL1F9) 2) binding of IL1F9 leads to the activation of NF-kappa-B 3) does not bind interleukin 1 alpha (IL1A) or interleukin 1 beta (IL-1B) Structure: - belongs to the interleukin-1 receptor family - contains 3 Ig-like C2-type domains - contains 1 TIR domain Compartment: - membrane; single-pass type 1 membrane protein

Related

interleukin-36 gamma; IL-1-related protein 2; IL-1RP2; interleukin-1 epsilon; IL-1 epsilon; interleukin-1 family member 9; IL-1F9; interleukin-1 homolog 1; IL-1H1 (IL36G, IL1E, IL1F9, IL1H1, IL1RP2, UNQ2456/PRO5737)

General

cell surface receptor

Properties

SIZE: MW = 65 kD entity length = 575 aa COMPARTMENT: plasma membrane MOTIF: immunoglobulin superfamily domain {20-111} MOTIF: N-glycosylation site {N41} cysteine residue {C42} MODIFICATION: cysteine residue {C95} N-glycosylation site {N59} cysteine residue {C95} MODIFICATION: cysteine residue {C42} N-glycosylation site {N109} immunoglobulin superfamily domain {126-211} MOTIF: N-glycosylation site {N127} cysteine residue {C146} MODIFICATION: cysteine residue {C195} N-glycosylation site {N184} cysteine residue {C195} MODIFICATION: cysteine residue {C146} immunoglobulin superfamily domain {222-318} MOTIF: N-glycosylation site {N234} cysteine residue {C249} MODIFICATION: cysteine residue {C316} N-glycosylation site {N250-N299} (3) cysteine residue {C316} MODIFICATION: cysteine residue {C249} transmembrane domain {336-356} TIR {381-539}

Database Correlations

OMIM 604512 UniProt Q9HB29 Pfam PF01582 Entrez Gene 8808 Kegg hsa:8808

References

  1. UniProt :accession Q9HB29
  2. SeattleSNPs http://pga.gs.washington.edu/data/il1rl2/