interleukin-1 receptor 9; X-linked interleukin-1 receptor accessory protein-like 2; IL-1 receptor accessory protein-like 2; IL1RAPL-2-related protein; IL-1R9; three immunoglobulin domain-containing IL-1 receptor-related 1; TIGIRR-1 (IL1RAPL2, IL1R9)

Structure: - belongs to the interleukin-1 receptor family - contains 3 Ig-like C2-type domains (immunoglobulin-like) - contains 1 TIR domain Compartment: membrane Expression: - detected at low levels in fetal & adult brain, including frontal lobe, temporal lobe & cerebellum - detected at very low levels in skin, liver, fetal ovary & in placenta

General

glycoprotein interleukin-1 receptor accessory protein (Three immunoglobulin domain-containing IL-1 receptor-related)

Properties

SIZE: entity length = 686 aa MW = 79 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-16} immunoglobulin superfamily domain {18-132} MOTIF: cysteine residue {C53} MODIFICATION: cysteine residue {C116} N-glycosylation site {N63} cysteine residue {C116} MODIFICATION: cysteine residue {C53} N-glycosylation site {N120} N-glycosylation site {N136} immunoglobulin superfamily domain {141-232} MOTIF: cysteine residue {C162} MODIFICATION: cysteine residue {C214} N-glycosylation site {N211} cysteine residue {C214} MODIFICATION: cysteine residue {C162} immunoglobulin superfamily domain {239-347} MOTIF: cysteine residue {C265} MODIFICATION: cysteine residue {C331} N-glycosylation site {N328} cysteine residue {C331} MODIFICATION: cysteine residue {C265} transmembrane domain {355-375} TIR domain {400-559}

Database Correlations

OMIM 300277 UniProt Q9NP60 PFAM correlations Kegg hsa:2628

References

UniProt :accession Q9NP60