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interleukin-18 receptor 1; IL1 receptor-related protein; IL-1Rrp; CD218 antigen-like family member A; CDw218a; CD218a (IL18R1, IL1RRP)
Function:
1) receptor for IL18
2) binding to IL18 leads to the activation of NF-kappa-B
3) associates with IL18RAP
4) does NOT bind IL1A or IL1B
Structure:
- belongs to the interleukin-1 receptor family
- contains 3 Ig-like C2-type domains (immunoglobulin-like)
- contains 1 TIR domain
Compartment: membrane
Expression:
- expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, heart
- NOT expressed in brain, skeletal muscle, pancreas, kidney
Pathology:
- high level of expression in Hodgkin's disease cell lines
Related
interleukin-18 receptor accessory protein; IL-18 receptor accessory protein; IL-18RAcP; accessory protein-like; AcPL; CD218 antigen-like family member B; CDw218b; IL-1R accessory protein-like; IL-1RAcPL; interleukin-1 receptor 7; IL-1R-7; IL-1R7; interleukin-18 receptor accessory protein-like; interleukin-18 receptor beta; IL-18R-beta; IL-18Rbeta; CD218b (IL18RAP IL1R7)
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
interleukin receptor
Properties
SIZE: MW = 62 kD
entity length = 541 aa
COMPARTMENT: plasma membrane
MOTIF: signal sequence {1-18}
immunoglobulin superfamily domain {33-121}
MOTIF: N-glycosylation site {N91}
N-glycosylation site {N102}
immunoglobulin superfamily domain {133-212}
MOTIF: cysteine residue {C140}
MODIFICATION: cysteine residue {C185}
N-glycosylation site {N150}
cysteine residue {C185}
MODIFICATION: cysteine residue {C140}
N-glycosylation site {N197}
N-glycosylation site {N203}
immunoglobulin superfamily domain {220-312}
MOTIF: N-glycosylation site {N236}
cysteine residue {C237}
MODIFICATION: cysteine residue {C298}
N-glycosylation site {N255}
N-glycosylation site {N297}
cysteine residue {C298}
MODIFICATION: cysteine residue {C237}
transmembrane domain {330-350}
TIR domain {373-523}
Database Correlations
OMIM 604494
UniProt Q13478
PFAM correlations
Entrez Gene 8809
Kegg hsa:8809
References
- Entrez Gene :accession 8809
- UniProt :accession Q13478