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interleukin-18-binding protein; IL-18BP; Tadekinig-alfa (IL18BP)
Function:
- isoform A binds to IL-18 & inhibits its activity
- inhibitor of the early TH1 cytokine response
Structure:
- N-glycosylated & O-glycosylated with core 1-like & core 2-like glycan
- O-glycan heterogeneity at Ser-53: hexhexNAc (major) & hex2hexNAc2 (minor).
- N-glycan heterogeneity at Asn-103: hex5hexNAc4 (minor), dhex1hex5hexNAc4 (major) & hex6hexNAc5 (minor)
- N-glycan at Asn-147: dhex1hex5hexNAc4
- contains 1 Ig-like C2-type domain
Compartment: secreted
Alternative splicing: named isoforms=3; A, B, D
Expression: strongly expressed in heart, lung, placenta, spleen
Related
interleukin-18; IL-18; Iboctadekin; interferon gamma-inducing factor; IFN-gamma-inducing factor; interleukin-1 gamma; IL-1 gamma (IL18, IGIF, IL1F4)
General
glycoprotein
secreted protein
Properties
SIZE: entity length = 194 aa
MW = 21 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-30}
Ser glycosylation site {S53}
immunoglobulin superfamily domain {65-166}
MOTIF: N-glycosylation site {N79}
cysteine residue {C86}
MODIFICATION: cysteine residue {C150}
N-glycosylation site {N94}
N-glycosylation site {N103}
N-glycosylation site {N147}
cysteine residue {C150}
MODIFICATION: cysteine residue {C86}
Database Correlations
OMIM 604113
UniProt O95998
Entrez Gene 10068
Kegg hsa:10068
References
UniProt :accession O95998