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interleukin-17 receptor E (IL-17 receptor E, IL-17RE, IL17RE)
Function:
- receptor which can activate the MAPK signaling pathway
- seems to function at or upstream of Ras
- isoform 2 & isoform 4 may be either cytoplasmic inactive or dominant active forms
- isoform 3 & isoform 5 may act as soluble decoy receptors
Compartment:
- isoform 1: membrane
- isoform 2: cytoplasm
- isoform 3: secreted
- isoform 4: cytoplasm
- isoform 5: secreted
Alternative splicing: named isoforms=5
Expression: expressed in selected tumor cell lines
Related
interleukin 17 receptor E-like (IL-17 receptor E-like, IL-17RE-like, IL17REL)
General
glycoprotein
interleukin-17 receptor (IL17R)
Properties
SIZE: entity length = 667 aa
MW = 75 kD
COMPARTMENT: cytoplasm
MOTIF: signal sequence {1-23}
N-glycosylation site {N318}
N-glycosylation site {N347}
N-glycosylation site {N364}
transmembrane domain {455-475}
Database Correlations
UniProt Q8NFR9
Pfam PF08357
Entrez Gene 132014
Kegg hsa:1320
References
UniProt :accession Q8NFR9