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interleukin-17 receptor B; IL-17 receptor B; IL-17RB; interleukin-17B receptor; IL-17B receptor; IL-17 receptor homolog 1; IL-17Rh1; IL17Rh1; cytokine receptor CRL4 (IL17RB, EVI27, IL17BR, UNQ2501/PRO19612)
Function:
- receptor for the proinflammatory cytokines IL17B & IL17E
- may play a role in controlling the growth &/or differentiation of hematopoietic cells
- interacts with DAZAP2
Structure: contains 1 SEFIR domain
Compartment:
- isoform 1: cell membrane
- isoform 2: secreted
Alternative splicing: named isoforms=2
Expression:
- expressed in several endocrine tissues
- expresses in fetal & adult liver, kidney, pancreas, testis, colon, brain & small intestine
- not detected in peripheral blood leukocytes, lymphoid organs, & most cell lines
Laboratory:
- HOXB13/IL17BR gene ratio
Notes:
- may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay
General
glycoprotein
interleukin-17 receptor (IL17R)
Properties
SIZE: entity length = 502 aa
MW = 56 kD
COMPARTMENT: plasma membrane
MOTIF: signal sequence {1-17}
N-glycosylation site {N67}
N-glycosylation site {N103}
N-glycosylation site {N156}
N-glycosylation site {N183}
N-glycosylation site {N197}
N-glycosylation site {N283}
transmembrane domain {293-313}
Database Correlations
OMIM 605458
UniProt Q9NRM6
Pfam PF08357
Entrez Gene 55540
Kegg hsa:5554
References
- UniProt :accession Q9NRM6
- SeattleSNPs
http://pga.gs.washington.edu/data/il17rb/