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CDw217; interleukin-17 receptor A; IL-17 receptor; CD217 (IL17RA, IL17R)
Function:
- receptor for IL17A
- binds its ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling
Structure: glycosylated
Compartment: membrane
Expression: widely expressed
Pathology:
- appears to play a role in psoriasis
Pharmacology:
- IL17A receptor antibody (brodalumab) is effective in treatment of psoriasis
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
interleukin-17 receptor (IL17R)
Properties
SIZE: entity length = 866 aa
MW = 96 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-32}
N-glycosylation site {N49}
N-glycosylation site {N54}
N-glycosylation site {N206}
N-glycosylation site {N225}
N-glycosylation site {N242}
N-glycosylation site {N265}
transmembrane domain {321-341}
glutamate-rich region {810-818}
MOTIF: glutamate residue (SEVERAL)
Database Correlations
OMIM 605461
UniProt Q96F46
Pfam PF08357
Entrez Gene 23765
Kegg hsa:2376
References
UniProt :accession Q96F46