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interleukin-17F; cytokine ML-1; interleukin-24; IL-24 (IL17F, IL-17F, IL24)
Function:
1) stimulates the production of other cytokines, including IL-6, IL-8 & GCSF
2) regulation of cartilage matrix turnover
3) stimulates monocyte & T-cell proliferation
4) inhibits angiogenesis.
Structure: homodimer; disulfide-linked
Compartment: secreted
Expression:
- expressed in activated, but not resting, CD4+ T-cells & activated monocytes
Pathology:
- defects in IL17F are the cause of familial candidiasis type 6
Related
interleukin-24; IL-24; melanoma differentiation-associated gene 7 protein; MDA-7; suppression of tumorigenicity 16 protein (IL24, MDA7, ST16)
General
glycoprotein
interleukin-17 (IL-17)
oligomerizing protein
Properties
CONFIGURATION: dimer
SIZE: MW = 17 kD
entity length = 153 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-20}
cysteine residue {C37}
MODIFICATION: cysteine residue {C127}
N-glycosylation site {N73}
cysteine residue {C92}
MODIFICATION: cysteine residue {C142}
cysteine residue {C97}
MODIFICATION: cysteine residue {C144}
cysteine residue {C127}
MODIFICATION: cysteine residue {C37}
cysteine residue {C142}
MODIFICATION: cysteine residue {C92}
cysteine residue {C144}
MODIFICATION: cysteine residue {C97}
Database Correlations
OMIM correlations
UniProt Q96PD4
Pfam PF06083
Entrez Gene 112744
Kegg hsa:112744
References
- Entrez Gene :accession 112744
- UniProt :accession Q96PD4
- Wikipedia; Note: interleukin-17 entry
http://en.wikipedia.org/wiki/interleukin_17