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interleukin-17E; interleukin-25; IL-25; IL-17E (IL25, IL17E, UNQ3120/PRO10272)
Function:
1) induces activation of NF-kappa-B
2) stimulates production of IL-8
3) proinflammatory cytokine
4) promotes Th2-type immune responses.
Compartment: secreted
Alternative splicing: named isoforms=2
Expression:
- expressed at low levels in brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, trachea
General
glycoprotein
interleukin-17 (IL-17)
Properties
SIZE: entity length = 177 aa
MW = 20 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-32}
cysteine residue {C110}
MODIFICATION: cysteine residue {C168}
cysteine residue {C115}
MODIFICATION: cysteine residue {C170}
N-glycosylation site {N136}
cysteine residue {C168}
MODIFICATION: cysteine residue {C110}
cysteine residue {C170}
MODIFICATION: cysteine residue {C115}
Database Correlations
OMIM 605658
UniProt Q9H293
Entrez Gene 64806
References
- Entrez Gene :accession 64806
- UniProt :accession Q9H293
- Wikipedia; Note: interleukin-17 entry
http://en.wikipedia.org/wiki/interleukin_17