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interleukin-15 (IL15, IL-15)
Function:
1) stimulates the proliferation of T-cell
- requires interaction of IL-15 with components of IL-2R, including IL-2R beta & IL-2R gamma but NOT IL-2R alpha.
Compartment:
- IL15-S48AA: secreted
- IL15-S21AA: cytoplasm, nucleus, NOT secreted
Alternative splicing: named isoforms=3
Expression:
- expressed in placenta, skeletal muscle > heart, lung, liver, kidney
- IL15S21AA is preferentially expressed in testis, thymus
Related
interleukin-15 receptor
General
glycoprotein
interleukin
Properties
SIZE: MW = 18 kD
entity length = 162 aa
COMPARTMENT: cytoplasm
MOTIF: signal sequence {1-29}
cysteine residue {C83}
MODIFICATION: cysteine residue {C133}
cysteine residue {C90}
MODIFICATION: cysteine residue {C136}
N-glycosylation site {N127}
cysteine residue {C133}
MODIFICATION: cysteine residue {C83}
cysteine residue {C136}
MODIFICATION: cysteine residue {C90}
Database Correlations
OMIM 600554
UniProt P40933
Pfam PF02372
Entrez Gene 3600
Kegg hsa:3600
References
- Taniguchi T
Cytokine signaling through nonreceptor protein tyrosine kinases.
Science 268:251 1995
PMID: 7716517
- Entrez Gene :accession 3600
- UniProt :accession P40933
- R&D systems' cytokine source book: IL-15
http://www.rndsystems.com/molecule_detail.aspx?m=1671
- Wikipedia; Note: interleukin-15 entry
http://en.wikipedia.org/wiki/interleukin_15