CD213a1; interleukin-13 receptor alpha-1; IL-13R-alpha-1; IL-13RA-1; cancer/testis antigen 19; CT19; CD213a1 (IL13RA1, IL13R, IL13RA)

Function: - binds IL13 with a low affinity - together with IL4R-alpha can form a functional IL-13 receptor for IL-13 - also serves as an alternate accessory protein to the common cytokine receptor gamma chain for IL4 signaling - interacts with TRAF3IP1 Structure: - the WSXWS motif appears to be necessary for proper protein folding, efficient intracellular transport & cell- surface receptor binding - the box 1 motif is required for JAK interaction &/or activation - belongs to the type I cytokine receptor family, type 5 subfamily Compartment: membrane Expression: - ubiquitous - highest levels in heart, liver, skeletal muscle & ovary - lowest levels in brain, lung & kidney - also found in B-cells, T-cells & endothelial cells

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein protein subunit

Properties

SIZE: entity length = 427 aa MW = 49 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-21} N-glycosylation site {N37} cysteine residue {C46} MODIFICATION: cysteine residue {C95} N-glycosylation site {N61} cysteine residue {C95} MODIFICATION: cysteine residue {C46} N-glycosylation site {N105} cysteine residue {C134} MODIFICATION: cysteine residue {C144} N-glycosylation site {N138} cysteine residue {C144} MODIFICATION: cysteine residue {C134} N-glycosylation site {N157} cysteine residue {C173} MODIFICATION: cysteine residue {C185} cysteine residue {C185} MODIFICATION: cysteine residue {C173} N-glycosylation site {N235} N-glycosylation site {N265} N-glycosylation site {N293} WSXWS motif {327-331} MOTIF: N-glycosylation site {N329} N-glycosylation site {N341} transmembrane domain {344-367} box1 motif SITE: 374-382 FOR-BINDING-OF: Janus kinase (JAK)

Database Correlations

OMIM 300119 UniProt P78552 Entrez Gene 3597 Kegg hsa:3597

References

UniProt :accession P78552